Medical Center – University of Freiburg (Germany) www.uniklinik-freiburg.de

 SCIDNET Principal Investigator: Toni Cathomen (toni.cathomen@uniklinik-freiburg.de)

UKLFR is one of the largest medical centers in Europe, with representations of all medical specialties. The medical faculty is part of the Albert-Ludwigs-University of Freiburg, which has put forward Immunology and Infectious Diseases as one of the five strategically supported research areas of the Medical Center. In order to support Freiburg’s leading role in immunology, the Federal Ministry of Education and Research has funded the setup of the Center for Chronic Immunodeficiencies (CCI) in 2008 and the Institute for Cell and Gene Therapy (IZG) in 2013. The IZG combines an established facility for diagnostic services with specialized personnel for GMP-compliant manufacturing processes, and research groups focusing on (i) the improvement of safe genome editing tools (incl. TALENs, CRISPR-Cas) for therapeutic applications in human stem cells, (ii) the development of disease models and cell therapies based on induced pluripotent stem cells, and (iii) the translation of genome editing for rare immunodeficiencies, HIV infection, and leukemia.